China's annual right piperazine demand is 3,500 tons, of which 90% of anhydrous piperazine, and the current domestic demand for the actual output was only one-seventh, and anhydrous piperazine has been formed production capacity is almost entirely dependent on imports. Piperazine also known as six hydrogen pyrazine, piperazine beiges triazine, the two nitrogen own ring, toxicity small, is an important pharmaceutical intermediates, mainly used for synthesis of anti-tuberculosis drugs and antibiotics, but also for the production of deworming agent. Its industrial products into anhydrous piperazine, Sanshui piperazine, six water piperazine and June 5 piperazine (in 65%) 4 specifications, with anhydrous piperazine maximum value, the most widely used international trade also anhydrous piperazine-based. Piperazine has wide application areas. In China, piperazine mainly for the pharmaceutical industry, can be synthesized piperazine phosphate, piperazine sulfate, norfloxacin, pipemidic acid, quinolone, rifampin. Also, vein - Ning is a new efficient antihypertensive agents, whose main component is prazosin; Theophylline acetate piperazine can be used to treat burn shock, hypertension appetite; piperazinyl various alcohols and their derivatives can be used in clinical anesthesia; piperazine-1-Alkylamino of quinoline and pyridine antimalarial activity with N, N '- bis (2-pyrazine) piperazine and N-2-pyridyl piperazine with painkillers; adipic acid piperazine, Citrate piperazine piperazine and other organic acid salts of the substances, is widespread use of insecticide-treated drug. In addition, some piperazine derivatives, such as N-methyl piperazine, N - ethyl piperazine are production ofloxacin, TU sparfloxacin the main raw material. In addition, piperazine can be used to synthetic textile auxiliaries, rubber vulcanization enhancers and preservatives, antioxidants, stabilizers, Surfactant prevent corrosion agent, defoamer, the production of polyurethane additives. World piperazine manufacturers mainly in the United States, Western Europe and Japan and other industrialized countries and regions, Among them, the United States Union Carbide Company, Dow Chemical Company, Texaco; Western Europe is Belgium's BASF (BASFAmewerpenNV), Germany's Bayer Company, Sweden Rexolin Chemical Company, BerdNoberSuface Chemical Company, Netherlands DowBenduxNV DelamineBV companies and companies; Japan's Tosoh a company SumitomoSeika Chemical Company, NipponNyukasai companies and Kawaken Fine Chemicals Corporation. At present, the world annual production of about 10,000 tons. China Chem net www.chemnet.com.cn finishing my piperazine major manufacturers east North pharmaceutical factory, Changzhou Jincheng Medicine Chemical Corporation, Changzhou petrochemical plants, Changzhou technical and economic development of Central Asia, Fifth Shanghai Pharmaceutical Group and Shanghai, the South China Pharmaceutical Group and Shanghai Dyestuff Industry, Guangxi Guilin Pharmaceutical Factory, Henan Xinxiang megacrysts chemical plants, Shandong Zibo medicine more than 10 chemical plants. But because of technical and quality reasons, the actual product only 7-8, and the specifications for more than six water piperazine, the total production capacity of about 800 tons of 4587, the actual annual output less than 500 tons. And anhydrous piperazine is has been developed but has not yet formed production capacity, technology to be perfected. Currently only Xinxiang megacrysts chemical and petrochemical plants in Changzhou has a pilot plant, the production is minimal and Only a year dozens of tons of products. And consumer, 2000, piperazine total consumption of 2,600 tons, The pharmaceutical industry consumption of which 2,200 tons of other aspects of consumption of 400 tons; total consumption in 2002 to 3,100 tonnes, of which 2,500 pharmaceutical industry spending tons, other aspects of consumption of 600 tonnes of the total consumption in 2003 to 3,500 tons, The pharmaceutical industry consumption of which 2,800 tons of other aspects of consumption 700 tons. From the output and the gap between the consumer can see, domestic piperazine are major gaps in the market, but Currently, 3,500 tons of demand for 4587, some 90% of anhydrous piperazine, Since almost no domestic anhydrous piperazine plant, it imports about as much as 2,800 tons. Six water piperazine market price of 200,000 to 22 million metric ton, anhydrous piperazine is as high as 500,000 yuan metric ton. This shows that the development of piperazine very broad market prospects. China has produced piperazine many manufacturers, but China piperazine synthesis technology has floundered for years, Piperazine domestic varieties, yield, quality and price with foreign products have a wide gap between result on the domestic market piperazine serious lack of production needs, not only the annual need to import a huge quantity of piperazine, but also import a considerable number of downstream products. From the application market, the contradiction between supply and demand continues to widen. Therefore, the proposed piperazine manufacturers of the joint research institutions, absorbing domestic and foreign advanced technology, development and construction of thousands of tonnes of production-scale devices to alleviate the domestic market supply and demand contradictions. Proceed from the long-term development, the proposed qualified domestic large petrochemical companies developing advanced technology piperazine, building with an annual output of 3,000 tons in size device from the fundamental solution to the shortage of domestic piperazine situation.